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Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.

Visser, Pieter Jelle (author)
Karolinska Institutet
Reus, Lianne M (author)
Gobom, Johan (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Jansen, Iris (author)
Dicks, Ellen (author)
Tsolaki, Magda (author)
Verhey, Frans R J (author)
Popp, Julius (author)
Martinez-Lage, Pablo (author)
Vandenberghe, Rik (author)
Lleó, Alberto (author)
Molinuevo, José Luís (author)
Engelborghs, Sebastiaan (author)
Freund-Levi, Yvonne (author)
Froelich, Lutz (author)
Sleegers, Kristel (author)
Dobricic, Valerija (author)
Hong, Shengjun (author)
Lovestone, Simon (author)
Streffer, Johannes (author)
Vos, Stephanie J B (author)
Bos, Isabelle (author)
Smit, August B (author)
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Scheltens, Philip (author)
Teunissen, Charlotte E (author)
Bertram, Lars (author)
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Tijms, Betty M (author)
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 (creator_code:org_t)
Cold Spring Harbor Laboratory, 2020
2020
English.
In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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  • Journal article (other academic/artistic)
Abstract Subject headings
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  • Alzheimer's disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity mediated by gene repression factors SUZ12 and REST. AD individuals with abnormal t-tau levels have increased CSF concentrations of plasticity proteins regulated by SUZ12 and REST. AD individuals with normal t-tau, on the contrary, have decreased concentrations of these plasticity proteins and increased concentrations in proteins associated with blood-brain and blood CSF-barrier dysfunction. Genomic analyses suggested that t-tau levels in part depend on genes involved in gene expression. The distinct plasticity abnormalities in AD as signaled by t-tau urge the need for personalised treatment.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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vet (subject category)
art (subject category)

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